Section hub
The compound guides
Thirty pages tiered by how much human evidence exists, including the water, route, and comparison pages every guide leans on.
Open the hubThe briefing
One email a week. The evidence, minus the hype.
Decadewise is an evidence-first longevity and biohacking briefing. We read the methods section, name the source on every figure, and leave the numbers intact so you can check them.
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Sources named on every figure
Reviewed by medical professionals
We disclose every conflict
Education only, never advice
What this is
Evidence first, with the arithmetic shown.
Longevity and biohacking coverage written the way a methods section reads. Every attributed figure carries the paper, the label, or the registry entry it came from, and the working is on the page.
Sources are named
Every attributed number links to its DOI, PubMed ID, or drug label. If a claim cannot be tied to a real source, we cut the claim rather than soften it.
Numbers stay intact
Trial doses, endpoints, and timepoints are reported as the source reported them, same arm and same population, never merged across studies to make a cleaner story.
We pick no doses
The calculators convert whatever gets typed into them. What is right for a body is a clinician's call with your labs in front of them, not ours.
The library
Everything published so far.
Seventy-nine pages in twelve groups, gathered by eight section hubs: the calculators, the arithmetic that joins a vial label to a syringe reading, the compound guides that set that math beside the trial record, the short organ-named peptides and where their record stops, the handling, classification, and lab-document pages behind all of it, and the converter packaged for any other site to host.
That directory is organised by substance and by arithmetic. The other way in is by who is reading: one page, five starting points, each one naming what has been tested in that population and what does not carry across to it.
Section hubs
8 pages
Section hub
The dosage calculators
Three per-compound converters, each carrying its own molecule's approved label record next to the same vial arithmetic.
Open the hubSection hub
The dose math tools
Four compound-agnostic converters: three run one equation in three directions for any vial, water amount and barrel scale, and one converts between the ways a concentration gets written.
Open the hubSection hub
Classification and legal status
Four pages separating receptor pharmacology from statutory definitions from anti-doping status, with the document named each time.
Open the hubSection hub
Certificates of analysis
Two pages on what a batch document reports, what an HPLC purity percent covers, and which tests are simply absent from it.
Open the hubSection hub
Handling and storage
Two pages on the freeze-dried solid in the vial, how it is made, and how much its appearance can honestly tell anyone.
Open the hubSection hub
Peptide dose math, worked out
The directory for the whole dose math cluster: calculators, explainers, compound guides, and the standard behind them.
Open the hubSection hub
Peptide bioregulators
Ten pages on the short Khavinson peptides named after organs, each one tracing what the retrieved record actually contains and where it stops.
Open the hub
Per-compound calculators
4 pages
Calculator
Tirzepatide dose calculator
Vial strength and water volume in, concentration and syringe units out, with the approved label figures set beside the arithmetic.
Open the calculatorCalculator
Semaglutide dose calculator
The same convert-only arithmetic for a semaglutide vial, alongside what the Ozempic and Wegovy labels state about their own pens.
Open the calculatorCalculator
BPC-157 dose calculator
Vial mass and water volume to concentration and syringe units, with the regulatory record on the compound left intact next to it.
Open the calculatorCalculator
PT-141
Enter vial mg and water mL, get concentration and syringe units. Convert only: it recommends no amount.
Read the guide
Dose math and tools
13 pages
Section hub
Peptide dose math, worked out
The directory for the whole cluster: calculators, explainers, compound guides, and the standard behind them.
Open the hubCalculator
Units to mg converter
Two-way conversion between syringe units and milligrams, for any vial, water amount, and U-100 or U-40 scale.
Open the toolCalculator
Reconstitution calculator
Vial size plus water volume to concentration, or a target concentration back to the water it needs.
Open the toolCalculator
Bac water calculator
A vial, an amount to measure, and a target syringe mark in; the bacteriostatic water volume out.
Open the toolCalculator
Concentration converter
One concentration in four expressions: mg per mL, mcg per mL, percent weight/volume and ratio strength.
Open the toolExplainer
What is a unit
A unit is a fixed fraction of a milliliter printed on the barrel. Where the mark came from, and what it cannot tell you.
Read the explainerExplainer
Concentration vs dose
One is a property of the liquid, the other is a mass. Confusing them is the root of most wrong unit counts.
Read the explainerExplainer
mcg vs mg
The thousand-fold line, why the two get swapped in posts, and what the swap costs once it reaches a syringe.
Read the explainerExplainer
U-100 vs U-40 syringes
Two barrel scales with two different volumes per mark, and the 2.5x error from reading one as the other.
Read the explainerExplainer
Bac water volume changes your units
Same vial, different water: how the reconstitution choice rewrites every unit count downstream of it.
Read the explainerExplainer
Storage after reconstitution
What labels and papers state about a mixed vial's shelf life, and which circulated numbers have a source behind them.
Read the explainerExplainer
Why two dose charts disagree
Every conversion chart smuggles in its own vial, water, and syringe assumptions. Match all three and they agree.
Read the explainerExplainer
Blend vials, and why the math breaks
A calculator can convert the total but never the split. What a multi-peptide vial makes unknowable.
Read the explainer
Tools for other sites
1 page
Embed
Embed the units to mg converter
The converter as a widget any site can host with one line. Free, no account, no cookies, attribution link required.
Get the snippet
Compound dosage guides
23 pages
Rich human data
Tirzepatide
What the SURMOUNT and SURPASS trials reported, the approved label schedule, and the research-vial units problem.
Read the guideRich human data
Semaglutide
STEP and SUSTAIN figures, the pen strengths, and the escalation schedule those posts describe.
Read the guideRich human data
Tesamorelin
Two phase 3 trials, a daily rhythm instead of a weekly one, and one narrow approved indication.
Read the guideLimited human data
CJC-1295
A real but small early human record, a development program that stopped, and what the community reports.
Read the guideLimited human data
Ipamorelin
The selectivity paper, early pharmacokinetics, and a phase 2 trial that missed its endpoint.
Read the guideResearch only
BPC-157
No completed randomized human trials, a large rodent record, and the units questions people ask anyway.
Read the guideResearch only
TB-500
The human record belongs to the parent molecule. The guide says so first, then works the vial math.
Read the guideResearch only
MOTS-c
A mitochondrial peptide with a discovery paper, human exercise data, and a worked vial example.
Read the guideResearch only
GHK-Cu
The studied lane is topical. The injectable lane has no human trials, and the guide treats that gap as the headline.
Read the guideApproved drug
Melanotan 1
Afamelanotide is an approved 16mg implant. The guide separates that record from the weight-based injection studies and the units math.
Read the guideTrial record
SS-31
The trial and label figures with route and population, and the units math by vial. SS-31 is elamipretide.
Read the guideTrial record
AOD-9604
A 2.8kg result at 12 weeks that missed its own significance test, and a 24-week trial whose primary endpoint was not met.
Read the guideUnapproved
Melanotan 2
Every figure traced to a source, with the population it came from, what a 10mg vial assayed at, and the units math.
Read the guideThin literature
PE 22-28
A seven-residue fragment of spadin, also written mini-spadin. One 2017 mouse paper carries nearly the whole record.
Read the guideNo human trial
KPV
What FDA's 2026 review found, the mouse and cell work behind it, and what a 0.1 percent cream actually holds.
Read the guideNo human trial
IGF-1 LR3
What the studies gave and to which species, why no human trial exists, and the half-life claim checked against its source.
Read the guideBlend decode
KLOW
No trials exist on the blend. The guide decodes the four components and reconciles the two reconstitution camps.
Read the guideBlend decode
GLOW
What a 70mg vial holds, what the evidence says about each of the three peptides, and why this page prints no dosing chart.
Read the guideBlend decode
Wolverine stack
What a Wolverine stack vial holds, how a 5mg/5mg label changes the units math, and what the one study that gave rats both peptides found.
Read the guideNo human trial
FOXO4-DRI
No human dosage exists. The animal studies used three different amounts by three different routes, and each is printed with its source.
Read the guideNo human trial
BPC-157, oral
It survives gastric juice, but no permeability assay, no oral bioavailability figure and no human oral study exist.
Read the guideTrial record
Kisspeptin-10
Every human amount on record, with the route it went in by and how long it ran: infusion rates, bolus doses, and the nmol to mcg math.
Read the guideThin literature
Selank
Every published dose is an animal figure, the human trials print none, and n-acetyl selank amidate has no literature at all.
Read the guide
Peptide bioregulators
10 pages
Limited human data
Epitalon
FDA counted three human studies of the tetrapeptide, and states it is a different substance from Epithalamin, the pineal extract behind the longevity numbers.
Read the pageLimited human data
Pinealon
The tripeptide Glu-Asp-Arg: one independent DNA study, one in vitro head-to-head, and three small human reports.
Read the pageLimited human data
Vesugen
Eleven papers name the tripeptide Lys-Glu-Asp. Seven gave it to people, all Russian-language abstracts, and what each measured.
Read the pageLimited human data
Vilon
The dipeptide Lys-Glu. Three Russian-language human trials exist; the rest of the record is cultured cells and mice.
Read the pageThin literature
Testagen
Every in-vivo study of the tetrapeptide KEDG is in hypophysectomized birds, and the one human paper tested a food supplement.
Read the pageNo human trial
Prostamax
Two rat papers from one Tomsk institute give doses a thousandfold apart, and the human data sits in a patent rather than a paper.
Read the pageNo human trial
Cardiogen
No human study of Ala-Glu-Asp-Arg exists, and the threefold survival figure comes from a patent, not a paper.
Read the pageNo human trial
Bronchogen
No human study at all. Two different sequences carry the name and weigh the same, and the lung findings are cultured cells and rats.
Read the pageNo human trial
Cortagen
Epitalon with proline in place of glycine. Four experiments report the two separately, and the only human data sits inside a patent.
Read the pageNo human trial
Cartalax
The tripeptide Ala-Glu-Asp: eight indexed experiments, all cells or animals, none in people, with every study and what it tested.
Read the page
Bacteriostatic water
3 pages
Explainer
What is bacteriostatic water
The label definition, how much preservative each presentation carries, the neonate warning, and where the circulated shelf life figure comes from.
Read the explainerComparison
Bacteriostatic vs sterile water
One is water for injection with benzyl alcohol added, the other has nothing added. What the preservative buys, and what each label says about reuse.
Read the comparisonComparison
Bacteriostatic water vs saline
Saline is salt water at the concentration of blood, bacteriostatic water carries no solute at all. The two differ on tonicity first, preservation second.
Read the comparison
Administration, as the labels specify it
3 pages
Label record
Subcutaneous vs intramuscular
What an approved label means when it names one route for its own product and rules the others out, and the absorption data behind that choice.
Read the explainerTrial record
Injection sites in the trials
Which body regions the registered protocols allowed the study drug to be given in, and how that entry carries forward into the approved label.
Read the explainerLabel record
Needle gauges and syringe sizes
Gauge is a tubing size standardized in ISO 9626, and the number runs backwards. What the pen and vial labels name for their own products.
Read the explainer
Compound comparisons
5 pages
Comparison
HGH vs peptides
Somatropin is the full growth hormone chain with approved uses of its own. The shorter sequences it gets compared to act one step upstream of it.
Read the comparisonComparison
SARMs vs peptides
Two different chemical classes that happen to share a marketplace: androgen receptor small molecules against chains of amino acids.
Read the comparisonComparison
Tirzepatide vs semaglutide
SURPASS-2 put both in one protocol, one population, and the same forty weeks, then reported every arm. What a single head-to-head cannot settle.
Read the comparisonComparison
Melanotan 1 vs 2
One is an approved MC1R drug, the other an unapproved cyclic peptide. What actually separates them, sourced.
Read the comparisonNaming
Follistatin 344 vs 315
Not rival products: FST-344 is the precursor and FS-315 the mature chain. The real split is 315 against 288.
Read the comparison
Legal status and classification
6 pages
Classification
Is MK-677 a SARM
Ibutamoren is a ghrelin receptor agonist and growth hormone secretagogue, not a SARM. The trial record, the anti-doping class, and the FDA position.
Read the explainerClassification
Is ostarine a steroid
Enobosarm binds the receptor testosterone binds but is not built on a steroid backbone. What the statutory definition covers, and what it leaves out.
Read the explainerClassification
Cardarine (GW501516)
A PPAR-delta agonist with no androgen receptor activity, the discovery program it came out of, and what the rodent carcinogenicity record states.
Read the explainerApproval record
PT-141 and bremelanotide
One approved product covering one narrow indication. What the label states, and what its Limitations of Use section explicitly excludes.
Read the explainerApproval record
Retatrutide approval
Not FDA approved. What Drugs@FDA returns, what the sponsor told the SEC about a 2027 filing, and where phase 3 stands.
Read the guideClassification
Retatrutide legal status
No approval anywhere, so it is not a prescription drug. What FDA calls it in its own warning letters.
Read the guide
Handling and storage
2 pages
Explainer
What is a lyophilized peptide
Frozen, then dried under vacuum so the ice turns straight to vapor. The three stages, the stresses each applies, and what sets a shelf life.
Read the explainerExplainer
Why a vial cake looks wrong
Cracked, cotton-like, or half empty. What the freeze-drying literature says each appearance is, and when it is inherent to the product.
Read the explainer
Reading a certificate of analysis
2 pages
Explainer
How to read a peptide COA
A certificate reports named tests, by named methods, against named criteria, for one batch. What each line measures, and which tests are absent.
Read the explainerExplainer
What HPLC purity does not cover
A purity figure is an area percent of what eluted and was detected. It cannot establish identity, sequence, endotoxin, sterility, or peptide content.
Read the explainerThe weekly briefing
One email a week. The evidence, minus the hype.
New calculators, new explainers, and the arithmetic behind the next confusing syringe photo. Free.
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How we stay honest
We disclose every conflict, then show you the data anyway.
We do not pretend to have zero ties. Our founder holds an affiliate interest, and we tell you exactly where. What we will not do is bend a finding to fit a sponsor. When a link pays us, it is marked. The evidence reads the same either way.
Every claim is sourced
If we cannot tie it to a real study, label, or registry entry, we cut it. No borrowed authority.
Commissions are labeled
You always know when a link earns us something. It never changes what the data says.
Null results get published
The studies that fell flat are in here too. Leaving them out is how a library becomes marketing.
The disclaimer
Every page is reviewed by medical professionals before it ships, and written with longtime biohackers who were doing this before it was a trend. Reviewed still does not mean prescribed: nothing here is medical advice.
It is research, trial data, and reported use, with the numbers intact so you can check them. For decisions about your body, see a doctor who can look at your labs.
Read the full methodology, sourcing rules, and corrections policy